The aim of the study was to prepare the buccal patches of salbutamol, the bronchodilator having oral bioavailability of 10.8%, using polymers like sodium alginate, carbopol-934P, PVA, and PVP in various proportions while glycerin as a plasticizer. The patches were prepared by solvent casting technique and were subjected to various evaluation parameters like weight uniformity, content uniformity, thickness uniformity, swelling index, folding endurance, surface pH, and in vitro release studies. The Fourier transform infrared spectroscopic studies revealed that there was no interaction between drug and polymers. The viscosities of the polymeric solutions used for formulations were determined using Brookfield viscometer. The tensile strength of the patches was determined using Universal strength testing machine and found satisfactory. In vitro release studies were conducted for drug loaded patches in phosphate buffer solution, pH 6.6. The patches exhibited 48.73 to 102.21% drug release in 45 min. Data of in vitro release from the patches were fit to different equations and kinetic models to explain release profiles. In vitro release followed zero order kinetics. Release of salbutamol from the patches containing sodium alginate followed Higuchi’s model and mechanism was diffusion rate limited. In vivo studies in human volunteers showed 41.88% drug absorption in 30 min from formulation containing sodium alginate. Good correlation among in vitro release and in vivo absorption of salbutamol was observed (R2= 0.986).
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